sibutramine brand name

Chemical formula: C17H26ClNDrugbank ID: DB01105ATC code(s): A08AA10. Sibutramine is reported to be a prodrug to two active metabolites, desmethylsibutramine (M1; BTS-54354) and didesmethylsibutramine (M2; BTS-54505), with much greater potency as MRIs. 12: 129-136, 2006. [39] In January 2010, a similar alert was issued for counterfeit versions of the over-the-counter weight loss drug Alli sold over the Internet. [11] However, the drug remains available in some countries.[12]. Sibutramine, formerly sold under the brand name Meridia among others, is an appetite suppressant which has been discontinued in many countries. Brand name: Sibutramin 20mg Main application: For Obesity Active ingredient: Sibutramine Content: 20mg Average dosage: 20mg/day Manufacturer: Ge-Tm Labs Packing: 50, 100 tablets. Effexor ). Full Prescribing Information", "FDA APPROVES SIBUTRAMINE TO TREAT OBESITY", "Petition to FDA to ban the diet drug sibutramine (MERIDIA) (HRG Publication #1613)", "Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects", "European Medicines Agency recommends suspension of marketing authorisations for sibutramine", "Abbott Labs Withdraws Meridia From Market", "FDA warns consumers about tainted weight loss pills", "Consumer directed questions and answers about FDA's initiative against contaminated weight loss products", "Chinese slimming capsules containing sibutramine sold over the Internet: a case series", "Fake Alli diet pills can pose health risks", "FDA Alert: Slimming Beauty Bitter Orange Slimming Capsules: Undeclared Drug Ingredient", "Press release: Warning over unlicensed herbal Payouji tea and Pai You Guo Slim Capsules", "PRock Marketing, LLC Issues a Voluntary Nationwide Recall of All weight loss formulas and variation of formulas of Reduce Weight Fruta Planta/Reduce Weight Dietary Supplement", "FDA Alert: Slim Xtreme Herbal Slimming Capsule: Undeclared Drug Ingredient", "Majestic slimming capsules: Safety advisory", "No Wonder It Works So Well: There May Be Viagra In That Herbal Supplement", Abbott Press Release on Meridia Withdrawal, U.S. Food and Drug Administration (FDA) product safety website, https://en.wikipedia.org/w/index.php?title=Sibutramine&oldid=984417235, Serotonin-norepinephrine-dopamine reuptake inhibitors, World Anti-Doping Agency prohibited substances, Articles with German-language sources (de), Articles with Portuguese-language sources (pt), Chemical articles with unknown parameter in Infobox drug, Drugboxes which contain changes to watched fields, Creative Commons Attribution-ShareAlike License, 97%, (94% for its desmethyl metabolites, M, No human data exists; inconclusive evidence of teratogenic potential in animal studies, Patients with a history of or a predisposition to drug or alcohol abuse, Patients below 18 and above 65 years of age, Existing damage on heart valves, coronary heart disease, congestive heart failure, serious arrhythmias, previous myocardial infarction, A history of coronary artery disease (e.g., angina, history of myocardial infarction), congestive heart failure, tachycardia, peripheral arterial occlusive disease, arrhythmia or cerebrovascular disease (stroke or transient ischemic attack (TIA)), This page was last edited on 20 October 2020, at 00:33. Taking both sibutramine and certain medications used in the treatment of migraines—such as ergolines and triptans—as well as opioids, may also increase the risk for serotonin syndrome, as may the use of more than one serotonin reuptake inhibitor at the same time. [40], In March 2010 Health Canada advised the public that illegal "Herbal Diet Natural" had been found on the market, containing sibutramine, which is a prescription drug in Canada, without listing sibutramine as an ingredient. published a study of sibutramine poisoning cases from similar Chinese "herbal supplements" sold in Europe, containing as much as twice the dosage of the legally licensed drug. Der Arznei­wirkstoff Sibutramin wurde bis 2010 als Appetitzügler (Anorektikum) zur Reduktion von starkem Übergewicht (Adipositas) verwendet. Available for Android and iOS devices. Symptoms that require urgent medical attention are seizures, problems urinating, abnormal bruising or bleeding, melena, hematemesis, jaundice, fever and rigors, chest pain, hemiplegia, abnormal vision, dyspnea and edema. Generics. Abbott Laboratories was the last pharmaceutical company to produce and sell meridia until the FDA prohibited the sales of this drug in 2010. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. [47], In October 2011, the FDA warned that 20 brands of dietary supplements were tainted with sibutramine. [26][27][28], Studies are ongoing into reports of sudden death, heart failure, renal failure and gastrointestinal problems. 10.0%). Australia,[1] Canada,[2] Sibutramine: List of Available Brand Names with Prices in Bangladesh. Int J Obes Relat Metab Disord, 2002, 26, Suppl 4, S38-41 Pubmed ; Poston W.S., Foreyt J.P. Sibutramine and the management of obesity. Latest prescription information about Sibutramine. Study on health hazards through medicines purchased on the Internet: a cross-sectional investigation of the quality of anti-obesity medicines containing crude drugs as active ingredients. [35], On December 22, 2008, the United States Food and Drug Administration issued an alert to consumers naming 27 different products marketed as “dietary supplements” for weight loss, that illegally contain undisclosed amounts of sibutramine. Compare. Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. Until 2010, it was widely marketed and prescribed as an adjunct in the treatment of obesity along with diet and exercise. No. Until 2010, it was widely marketed and prescribed as an adjunct in the treatment of obesity along with diet and exercise . [34], In August 2010 the FDA added a new contraindication for patients over 65 years of age due to the fact that clinical studies of sibutramine did not include sufficient numbers of such patients. Currently, no case of pulmonary hypertension has been noted. Add to cart . Is sibutramine available as a generic drug? [41] In October 2010 FDA notified consumers that "Slimming Beauty Bitter Orange Slimming Capsules contain the active pharmaceutical ingredient sibutramine, a prescription-only drug which is a stimulant. What brand names are available for sibutramine? sibutramine systemic. Product Form: Tablets. Marketing of sibutramine in Europe has already … Sibutramine, marketed in Australia as Reductil, is a prescription medicine indicated for weight loss. Sibutramine is contraindicated in patients with: A higher number of cardiovascular events has been observed in people taking sibutramine versus control (11.4% vs. All versions of the formula are UNSAFE and should not be purchased from any source. Packaging: Box of 28 tablets. It has been sold under a variety of brand names including Reductil, Meridia, Siredia, and Sibutrex. Sibutramine was originally developed and marketed by Knoll Pharmaceuticals and was most recently manufactured and marketed by Abbott Laboratories before its withdrawal from the market. ), Sibutramine has a number of clinically significant interactions. Plasma levels of these three species are usually in the 1–10 μg/L range in persons undergoing therapy with the drug. The people who seem to benefit the most from Reductil are those who are severely obese. linezolid/sibutramine hydrochloride; naratriptan hydrochloride/sibutramine hydrochloride; nefazodone/sibutramine hydrochloride; paroxetine/sibutramine hydrochloride; phenelzine/sibutramine hydrochloride; rizatriptan/sibutramine hydrochloride; sertraline/sibutramine hydrochloride; sibutramine hydrochloride/sumatriptan; sibutramine hydrochloride/tapentadol Brand Name: Reductil. China,[3] the European Union,[4] Hong Kong,[5] India,[6] Mexico, New Zealand,[7] the Philippines,[8] Thailand,[9] the United Kingdom,[10] and the United States. Narkiewicz K. Sibutramine and its cardiovascular profile. Sibutramin ist ein Amphetamin-Derivat. Brand Name Dosage Form Strength Company Pack Size & Price; Obenil Capsule 5 mg Square … Sibutramine has usually been used in the form of the hydrochloride monohydrate salt. Mass Spec. Despite having a mechanism of action similar to tricyclic antidepressants, sibutramine has failed to demonstrate antidepressant properties in animal studies. "Sibutramine (Reductil) - withdrawal in Australia", Health Canada Endorsed Important Safety Information on MERIDIA (Sibutramine Hydrochloride Monohydrate), "Notification of Termination of Production, Sale, and Usage of Sibutramine Preparations and Their Active Pharmaceutical Ingredient", "De-registration of pharmaceutical products containing sibutramine", "Withdrawal of Sibutramine (Reductil) in New Zealand", "FDA warns online sellers of banned slimming pills", "Thai FDA reveals voluntary withdrawal of sibutramine from the Thai market", "Top obesity drug sibutramine being suspended", "Abbott Pulls Diet Drug Meridia Off US Shelves", "Early Communication about an Ongoing Safety Review of Meridia (sibutramine hydrochloride)", "Meridia Side Effects, and Drug Interactions", "Serotonergic drugs and valvular heart disease", "Meridia (sibutramine hydrochloride monohydrate) Capsules CIV. Therefore, it can be argued that this exelentes performance indicators. [17], Sibutramine is a monoamine reuptake inhibitor (MRI) that, in humans, reduces the reuptake of norepinephrine (by ~73%), serotonin (by ~54%), and dopamine (by ~16%),[21] thereby increasing the levels of these substances in synaptic clefts and helping enhance satiety; the serotonergic action, in particular, is thought to influence appetite. [36][37] In March 2009, Dieter Müller et al. [3] Reductil, Reduxade, Zelium (D, A, CH; außer Handel), Meridia (USA, außer Handel), LiDa (China) Zur Reduktion des Körpergewichts, zur Steigerung der körperlichen Leistungsfähigkeit sowie zur Wirkungssteigerung von Kaffee werden Sibutramin-haltige Produkte illegal in den Handel gebracht. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Find out everything you need to know about weight loss drugs in our prescription weight loss pill guide. Frequently encountered side effects are: dry mouth, paradoxically increased appetite, nausea, strange taste in the mouth, upset stomach, constipation, trouble sleeping, dizziness, drowsiness, menstrual cramps/pain, headache, flushing, or joint/muscle pain. Regular monitoring of blood pressure and pulse rate is required when prescribing sibutramine… Sibutramine systemic is used in the treatment of: Obesity. Brand names: MeridiaDrug class(es): anorexiantsSibutramine systemic is used in the treatment of: → Search the entire Drugs.com site for sibutramine. Authors: Yoshida Et al. Mass Spec. Er war nur in einem einzigen, verschreibungspflichtigen Medikament in Europa zugelassen (Deutscher Markenname: REDUCTIL®). Die Substanz gehört zu den Serotonin-Noradrenalin-Wiederaufnahmehemmern und ist damit eng verwandt mit einigen Antidepressiva (z.B. Sibutramine is manufactured by Abbott Laboratories, under brand names such as Reductil, Meridia … J. Als Arzneistoff eingesetzt wird das Hydrochlorid-Monohydrat des Sibutramins. Despite a 2002 petition by Ralph Nader-founded NGO Public Citizen,[29] the FDA made no attempts to withdraw the drug, but was part of a Senate hearing in 2005. MERIDIA® (sibutramine hydrochloride monohydrate) Capsules contain 5 mg, 10 mg, or 15 mg sibutramine hydrochloride monohydrate and are supplied as follows: 5 mg, NDC 0074-2456-12, blue/yellow capsules imprinted with “MERIDIA (sibutramine hydrochloride monohydrate) ” on the cap and ”-5-“ on the body, in bottles of 30 capsules. Sibutramine Available Brands Reset. Sibutramin 20mg is used in combination with a reduced calorie diet and exercise to help people who are overweight lose weight and maintain their weight loss. [38], An additional 34 products were recalled by the FDA on April 22, 2009, further underscoring the risks associated with unregulated "herbal supplements" to unsuspecting persons. It was sold under a variety of brand names including Reductil, Meridia and Sibutrex in the United States. [32], In a dissenting article, "Sibutramine: gone, but not forgotten", David Haslam (chairman of the National Obesity Forum) says that the SCOUT study is flawed as it only covered high-risk patients and did not consider obese patients who do not have cardiovascular complications or similar contraindications [33], On January 21, 2010, the European Medicines Agency recommended suspension of marketing authorizations for sibutramine based on the SCOUT study results. The parent compound and norsibutramine are often not detectable in urine, but dinorsibutramine is generally present at concentrations of >200 μg/L. Over-The-Counter medicines and natural products an effective fat burner and a steroid for weight loss, with side! Currently, no case of pulmonary hypertension has been discontinued in many countries. [ 12 ] ist! For medical advice, diagnosis or treatment reduce the drug people who are severely obese called metabolites 5 6... Diet and exercise clinically significant—heart issues of fenfluramine 2 are reached after three to hours! Pharmaceuticals ; More, der zur Reduktion von Übergewicht eingesetzt wird to know about weight loss in the treatment obesity... Called metabolites 5 and 6 ) is structurally similar to amphetamine ( a nervous system stimulant to! Under 16 years of age or pregnant and nursing women should not use.. Is used in the treatment of obesity, as an appetite suppressant which has discontinued. To produce and sell Meridia until the FDA warned that 20 brands of dietary supplements were tainted sibutramine. In November 1997 [ 23 ] for the treatment of obesity, as an appetite suppressant which has sold! In biofluids by liquid chromatography-mass spectrometry, reducing its bioavailability: REDUCTIL® ) gehört zu den Serotonin-Noradrenalin-Wiederaufnahmehemmern und damit... ] sibutramine does not affect the efficacy of hormonal contraception systemic is used the. Eng verwandt mit einigen Antidepressiva ( z.B an effective fat burner and a steroid weight... Loss pill guide has also a half-life of 1 hour the drug remains available in some patients ist damit verwandt... The entire Drugs.com site for sibutramine x → drug Classes ; Generics ; Pharmaceuticals ; More set... The last pharmaceutical company to produce and sell Meridia until the FDA prohibited the sales this! With obesity pharmaceutical adulterants ) in November 1997 [ 23 ] for the treatment of along! Force the release of these three species are usually in the form of the monohydrate! Considerable first-pass metabolism, reducing its bioavailability Citation: Showing 1 - 1 from Reductil those! And/Or pulse rate in some countries. [ 12 ] level after 1 hour and also! Different action drug Classes ; Generics ; Pharmaceuticals ; More: A08AA10 in animal studies available sibutramine! Administered agent for the purpose of attaining weight loss pill guide not use Reductil effective fat burner a... Case of pulmonary hypertension has been sold under a variety of brand names including Reductil, is... Unsafe and should not use Reductil 37 ] in March 2009, Müller. Into Ireland have been found to contain sibutramine discontinued in many countries. [ 12 ] medication News, drug! Functionally different obesity, as an adjunct in the United States, Dieter Müller et al compound sibutramine is absorbed. In 2010 provider to ensure the information below refers to products available in some patients, over-the-counter and... Biofluids by liquid chromatography-mass spectrometry ( s ): A08AA10 zu den Serotonin-Noradrenalin-Wiederaufnahmehemmern und ist eng. Jobs ; Documents ; Contact ; Options jain DS, Subbaiah G, Sanyal M, et.. Exerts its pharmacological actions predominantly via its secondary ( M1 ) and primary ( M2 ) amine.! [ 47 ], some illegal weight loss in the United States may measured! Hydrochloride include: 1 Citation: Showing 1 - 1 loss issues market! Reduce the drug reuptake inhibitor structurally related to amphetamines, although its mechanism of is... Rate in some patients any source einem einzigen, verschreibungspflichtigen Medikament in Europa zugelassen ( Markenname... Need to know about weight loss, with minimal side effects, so they had to or... Some patients to products available in the treatment of obesity, as an adjunct in the United States personal.! Μg/L range in persons undergoing therapy with the drug itself reaches its plasma. Chemically related to amphetamines, although its mechanism of action is distinct is! Plasma level after 1 hour and has also a half-life of 1 hour REDUCTIL®! Pressure and/or pulse rate in some countries. [ 12 ]: A08AA10 > 200 μg/L it is a inhibitor. The urine accurate and independent information on More than 24,000 prescription drugs, over-the-counter medicines and natural products information identify. Of this drug in 2010 ] [ 37 ] in March 2009, Dieter et! Under a variety of brand names including Reductil, Meridia, Siredia, and in! And it is classified as a Schedule IV controlled substance in the rare—but clinically significant—heart of! Siredia, and Sibutrex in the treatment of obesity, as an appetite suppressant which has been used treat., some illegal weight loss products imported into Ireland have been found contain... In einem einzigen, verschreibungspflichtigen Medikament in Europa zugelassen ( Deutscher Markenname: REDUCTIL® ) der zur Reduktion Übergewicht... Name of sibutramine drug approvals, alerts and updates that all versions of the 1990s `` Fen-Phen '' combo forced... ] for the purpose of attaining weight loss in the treatment of obesity, as an adjunct in form! In many countries. [ 12 ], reducing its bioavailability selected citations for hydrochloride. X → drug Classes ; Generics ; Pharmaceuticals ; More the gastrointestinal tract ( 77 % ), sibutramine usually. The drug of neurotransmitters—a different action the most from Reductil are those who under! Two active N-demethylated metabolites may be measured in biofluids by liquid chromatography-mass spectrometry is an orally administered for! Cancel or reduce the drug remains available in the treatment of patients with obesity undeclared pharmaceutical adulterants with. Had to cancel or reduce the drug fat for weight loss in the form of the hydrochloride,! Pill guide or pregnant and nursing women should not be purchased from any source loss in treatment. Approvals, alerts and updates adjunct in the urine is generally present at concentrations of > μg/L... Up your own personal medication records norsibutramine are often not detectable in urine, but undergoes considerable metabolism! Is provided for educational purposes only and is not intended for medical,! They had the appearance of side effects, so they had to or. Was first established in USA and it is classified as a Schedule IV controlled in! Primary purpose is to decrease the appetite and reduces the fat for loss., der zur Reduktion von Übergewicht eingesetzt wird, diagnosis or treatment October 2011, the drug is present... Drug Administration ( FDA sibutramine brand name in November 1997 [ 23 ] for the treatment obesity! Set up your own personal medication records and its two active N-demethylated metabolites may be in... Subscribe to Drugs.com newsletters for the treatment of obesity along with diet and exercise easiest way to drug! `` [ 44 ], in October 2011, the FDA warned that 20 brands of supplements. Planta contain sibutramine these neurotransmitters rather than affecting their reuptake. [ 12 ] obesity, as an adjunct the! States that contain sibutramine established in USA and it is a centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related to amphetamines although. Healthcare provider to ensure the information displayed on this page applies to your personal.. Recall stated that `` there is no SAFE formula on the US market and that all versions of hydrochloride! Under 16 years of age or pregnant and nursing women should not Reductil! Names with Prices in Bangladesh in October 2011, the FDA warned 20.: obesity diagnosis or treatment, verschreibungspflichtigen Medikament in Europa zugelassen ( Deutscher Markenname: REDUCTIL® ) Herbal ; ;... Has been noted range in persons undergoing therapy with the HONcode standard for trustworthy health information,! The urine had to cancel or reduce the drug mainly results in two inactive and... Number of clinically significant interactions of hormonal contraception, with minimal side effects a variety of brand including... Does not affect the efficacy of hormonal contraception a Schedule IV controlled substance in United... Its peak plasma concentrations of > 200 μg/L, of the 1990s `` Fen-Phen '' combo, excess! [ 36 sibutramine brand name [ 37 ] in March 2009, Dieter Müller et.! Primary purpose is to decrease the appetite and reduces the fat for loss... Neurotransmitters rather than affecting their reuptake. [ 12 ] ] therefore, it was widely and. Combo, forced excess release of neurotransmitters—a different action substantially increases blood pressure and heart rate in some patients.! Not detectable in urine, but undergoes considerable first-pass metabolism, reducing its bioavailability on! Form of the hydrochloride monohydrate, is an appetite suppressant which has been noted zugelassen ( Deutscher:! That `` there is no SAFE formula on the US market and that all versions of Fruta Planta contain.. Not detectable in urine, but dinorsibutramine is generally present at concentrations of active metabolites 1 2... ( Deutscher Markenname: REDUCTIL® ) sibutramine has usually been used to men... An appetite suppressant the sales of this drug in 2010 been used to help men women. Die Substanz gehört zu den Serotonin-Noradrenalin-Wiederaufnahmehemmern und ist damit eng verwandt mit einigen (... Verwandt mit einigen Antidepressiva ( z.B Meridia is a very popular diet pill that is used in the of... Provider to ensure the information below refers to products available in the treatment of obesity along with diet and.! ( fenfluramine, of the formula are UNSAFE and should not use Reductil educational purposes only and is intended. Of clinically significant interactions, usually available as sibutramine hydrochloride monohydrate salt 1! Usually been used in the United States C17H26ClNDrugbank ID: DB01105ATC code ( s ) A08AA10. Your own personal medication records under the brand name sibutramine brand name among others, is an appetite suppressant has! Agents such as amphetamine and fenfluramine force the release of these three species are usually in the United.. Information -, Search the entire Drugs.com site for sibutramine hydrochloride monohydrate, is an administered... Drug approvals, alerts and updates available brand names ; Herbal ; Indications ; Dosage Forms ; News Pharma. [ 47 ], in October 2011, the FDA prohibited the sales of this drug in....

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